Enzymatic O-Methylation of Epinephrine and Other Catechols

Enzymatic O-methylation of epinephrine and other catechols.

Many studies in vitro have implicated cytochrome oxidase and monoamine oxidase in the metabolism of epinephrine and other cateehol amines (2). However, no evidence for the participation of cytochrome oxidase in the metabolism of epinephrine in viva has been obtained. Furthermore, several investigations have indicated that monoamine oxidase plays only a minor role in the inactivation of epinephr...

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Enzymatic 0-Methylation of Epinephrine and Other Catechols*

Many studies in vitro have implicated cytochrome oxidase and monoamine oxidase in the metabolism of epinephrine and other cateehol amines (2). However, no evidence for the participation of cytochrome oxidase in the metabolism of epinephrine in viva has been obtained. Furthermore, several investigations have indicated that monoamine oxidase plays only a minor role in the inactivation of epinephr...

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Dynamic aspects of enzymatic O-methylation and -demethylation of catechols in vitro and in vivo.

The importance of 0-methylation of catecholamines and other catechols as a metabolic pathway has been amply shown (l-4). The isolation of “Substanz Y,” a p-O-methylcatechol derivative from beef adrenal glands (5), and the occurrence of p-o-methylcatechol derivatives in urine (6) are suggestive of p-o-methylation in viva. Previous studies (7) have shown that in vitro the enzyme 0-methyltransfera...

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Dynamic Aspects of Enzymatic 0-Methylation and -Demethylation of Catechols in Vitro and in Viva

The importance of 0-methylation of catecholamines and other catechols as a metabolic pathway has been amply shown (l-4). The isolation of “Substanz Y,” a p-O-methylcatechol derivative from beef adrenal glands (5), and the occurrence of p-o-methylcatechol derivatives in urine (6) are suggestive of p-o-methylation in viva. Previous studies (7) have shown that in vitro the enzyme 0-methyltransfera...

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Metabolism of epinephrine and other sympathomimetic amines.

CIRCULATORY ADAPTATIONS IN HYPOXIA. . . . . . . . . . . . . 3. I. Korner DISTR~JTION OF INSPIRED GAS IN LUNGS Arend Bouhuys and Gunnar Lundin METABOLISM OF EPINEPHRINE AND OTHER SYMPATHOMIMETIC AMINES Julius Axelrod TEMPORAL CHARACTERISTICS OF THYROID ACTIVITY. . . . Ui’f Siiderberg HOMOGRAFT SENSITIVITY. . . . . . . . . . . . . . . . . . . . . . H. Sherwood Laurence TRANSPLANTATION OF NORMAL T...

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Enzymatic O-Methylation of Epinephrine and Other Catechols

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